Been done a lot, predominantly with the explorer rear.
The pins are about .5" wider total, there is typically enough play in the leafs to bolt them up, but if you're using blocks at all, you can set the pins and the hole side by side and it's almost perfect, similar to the rear offset spacers used in trucks to center up the wheels in the rear wheel wells, just turned out.
What are you doing for rear swaybar? I undestand the standard S10 rear bar does not fit, though the S10Blazer bar may, and the exloder bar would require 100% custom mounting on the frame side.
Are you using S10 shock plates?